+91-80-22932659 / 22932548

Tanweer Hussain

Associate Professor

Research

The synthesis of proteins using genetic information is a fundamental process in all life forms. Although translation is a fundamental and indispensable process, many of its aspects are poorly understood. Our lab employs biochemical, mutational, and structural biology approaches to understand the molecular details of various steps involved in protein synthesis and to figure out how it is regulated. Understanding protein synthesis and its regulation will be beneficial for many human disorders and cancers and for the development of novel therapeutic strategies against bacterial, fungal, and viral infections.

 

Selected Publications

  • Das D, Hussain T#, eLife (2025) https://doi.org/10.7554/eLife.107788.1.
  • Datey A, Sharma P, Khaja FT, Rahil H, Hussain T# Biochemistry (2025) 64 (3), 600-608.
  • Villamayor-Belinchón L*, Sharma P&, Gordiyenko Y, Llácer JL#, Hussain T# Nucleic Acids Research, (2024) 52 (18), 11317-11335.
  • Mishra RK, Sharma P, Khaja FT, Uday AB, and Hussain T#. Cryo-EM structure of wheat ribosome reveals unique features of the plant ribosomes. Structure (2024). Mar 4:S0969-2126(24)00045-5. doi: 10.1016/j.str.2024.02.006
  • M Afsar, R Narayan, MN Akhtar, Das D, H Rahil, Nagaraj SK, SM Eswarappa, S Tripathi, Hussain T#. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2. eLife (2022);11:e74877 doi: 10.7554/eLife.74877
  • Basu I, Gorai B, Chandran T, Maiti PK# and Hussain T#. Selection of start codon during mRNA scanning in eukaryotic translation initiation. Commun Biol. (2022) 5:587; doi: https://doi.org/10.1038/s42003-022-03534-2
  • Mishra RK, Datey A, Hussain T#. mRNA recruiting eIF4 factors involved in protein synthesis and its regulation. Biochemistry (2020): 59: 34-46. doi: 10.1021/acs.biochem.9b00788.

All Publications

People

Postdocs and Ph.D. Students
Ishmat Ara Yasmin
PhD, MAHE Bangalore
Deepakash Das
M.Sc in Biotechnology, Savitribai Phule Pune University
Prafful Sharma
M.Sc Microbiology, Savitribai Phule Pune University
Darshan Yadav
M.S: Indian Institute of Sciences
Shubham Ghai
M.Sc. in Biotechnology
Shahil Alam
M.Sc.
Vivek Singh Pal
M.Sc in Botany, Banaras Hindu University
Shailya Gupta
M.Sc, Banaras Hindu University
Satyajeeb Palai
Surabhi Chandra
BS-MS dual degree from IISER Berhampur, Odisha
Ankita Poddar
M.Sc
Project fellows and MSc students
Arpan Tapadar
BS Biology Major Ongoing at IISc
Rajath Shivanna
MSc Ongoing in Life Sciences at IISc;
Tuban Touhidur Rohman
M.Sc : Ongoing in Life Sciences at IISc;