Tanweer Hussain

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Associate Professor

Research

The synthesis of proteins using genetic information is a fundamental process in all life forms. Although translation is a fundamental and indispensable process, many of its aspects are poorly understood. Our lab employs biochemical, mutational, and structural biology approaches to understand the molecular details of various steps involved in protein synthesis and to figure out how it is regulated. Understanding protein synthesis and its regulation will be beneficial for many human disorders and cancers and for the development of novel therapeutic strategies against bacterial, fungal, and viral infections.

Selected Publications

Mishra RK, Sharma P, Khaja FT, Uday AB, and Hussain T#. Cryo-EM structure of wheat ribosome reveals unique features of the plant ribosomes. Structure (2024). Mar 4:S0969-2126(24)00045-5. doi: 10.1016/j.str.2024.02.006
Uday AB*, Mishra RK*, and Hussain T#. (2023). Initiation factor 3 bound to the 30S ribosomal subunit in an initial step of translation. Proteins. (2023); 1‐8. doi: 10.1002/prot.26655
M Afsar, R Narayan, MN Akhtar, Das D, H Rahil, Nagaraj SK, SM Eswarappa, S Tripathi, Hussain T#. Drug targeting Nsp1-ribosomal complex shows antiviral activity against SARS-CoV-2. eLife (2022);11:e74877 doi: 10.7554/eLife.74877
Basu I, Gorai B, Chandran T, Maiti PK# and Hussain T#. Selection of start codon during mRNA scanning in eukaryotic translation initiation. Commun Biol. (2022) 5:587; doi: https://doi.org/10.1038/s42003-022-03534-2
Singh J*, Mishra RK*, Shreya AA, Hussain T#, Varshney U# The initiation factor 3 (IF3) residues interacting with initiator tRNA elbow modulate the fidelity of translation initiation and growth fitness in Escherichia coli. Nucleic Acids Res. (2022): 50(20):11712-11726. https://doi.org/10.1093/nar/gkac1053
Kumar R, Afsar M, Khandelwal N, Chander Y, Riyesh T, Dedar RK, Gulati BR, Pal Y, Barua S, Tripathi BN#, Hussain T#, Kumar N#. Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E. Antiviral Res. (2021):189,105056. doi: 10.1016/j.antiviral.2021.105056.
Mishra RK, Datey A, Hussain T#. mRNA recruiting eIF4 factors involved in protein synthesis and its regulation. Biochemistry (2020): 59: 34-46. doi: 10.1021/acs.biochem.9b00788.